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Nitric Oxide

A gas the body makes to carry signals between cells, best known for relaxing blood vessels.

On the Evidence Gradient

IEstablished mechanismsIIMixed evidenceIIITheoretical biophysicsIVExperiential wellness art
  • Tier INitric oxide is a signaling gas that relaxes blood vessels.
  • Tier INitric oxide can bind cytochrome c oxidase and compete with oxygen.
  • Tier IIILight may release nitric oxide from cytochrome c oxidase and let respiration resume; this is a proposed mechanism.

Tiers rate claims, not devices. How the Evidence Gradient works

Nitric oxide is a gas that carries signals in the body. One cell makes it, it passes through membranes, and it changes what another cell does. Its role in the cardiovascular system, where it relaxes blood vessels, earned Robert Furchgott, Louis Ignarro, and Ferid Murad the 1998 Nobel Prize in Physiology or Medicine (Nobel Assembly at Karolinska Institutet, 1998).

Nitric oxide also binds to cytochrome c oxidase in the mitochondria, where it competes with oxygen and slows the enzyme. One proposed mechanism for photobiomodulation is that absorbed light knocks nitric oxide loose, so that oxygen can return and respiration can resume (de Freitas & Hamblin, 2016).

Where the evidence stands

Nitric oxide signaling is standard physiology. Its release from cytochrome c oxidase by light is a proposed mechanism, part of what researchers call the leading hypothesis for photobiomodulation.

References

de Freitas, L. F., & Hamblin, M. R. (2016). Proposed mechanisms of photobiomodulation or low-level light therapy. IEEE Journal of Selected Topics in Quantum Electronics, 22(3), 348–364. https://doi.org/10.1109/JSTQE.2016.2561201

Nobel Assembly at Karolinska Institutet. (1998, October 12). The Nobel Prize in Physiology or Medicine 1998 [Press release]. NobelPrize.org. https://www.nobelprize.org/prizes/medicine/1998/press-release/

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