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Reactive Oxygen Species (ROS)

Reactive forms of oxygen that every cell makes; at low levels they carry signals, and at high levels they cause damage.

On the Evidence Gradient

IEstablished mechanismsIIMixed evidenceIIITheoretical biophysicsIVExperiential wellness artFloorClaims we do not make
  • Tier ICells make ROS as a normal part of using oxygen; low levels signal and high levels damage.
  • Below the floorBroad antioxidant compounds prevent disease by removing ROS; this has not held up in clinical trials.

Tiers rate claims, not devices. How the Evidence Gradient works

Reactive oxygen species, or ROS, is an umbrella term for reactive forms of oxygen that are a normal part of living with oxygen. At high levels they damage molecules, a state researchers call oxidative distress. At low, physiological levels they work as signals that help cells adapt to change and stress, a state called oxidative eustress (Sies & Jones, 2020).

That double role helps explain the biphasic dose response in photobiomodulation. In lab studies, mitochondrial ROS rose in two separate peaks as the light dose increased, and researchers suggest that ROS acting as a helpful signal at low levels and a harmful agent at high levels may partly explain the pattern (Huang et al., 2011).

As well, broad antioxidant compounds meant to wipe out ROS have not succeeded in clinical trials at preventing or slowing disease (Sies & Jones, 2020). More antioxidant is not automatically better.

References

Huang, Y.-Y., Sharma, S. K., Carroll, J., & Hamblin, M. R. (2011). Biphasic dose response in low level light therapy: An update. Dose-Response, 9(4), 602–618. https://doi.org/10.2203/dose-response.11-009.Hamblin

Sies, H., & Jones, D. P. (2020). Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nature Reviews Molecular Cell Biology, 21(7), 363–383. https://doi.org/10.1038/s41580-020-0230-3

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