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Triterpenes

Fat-soluble compounds found richly in reishi, drawn out of the mushroom with alcohol rather than water.

Also called triterpenoids · triterpenoid

On the Evidence Gradient

IEstablished mechanismsIIMixed evidenceIIITheoretical biophysicsIVExperiential wellness art
  • Tier IPolysaccharides and triterpenes are the two main groups of active compounds in reishi.
  • Tier IIIReishi triterpenes calm inflammation in people. Shown in cell and animal studies, not yet established in human trials.

Tiers rate claims, not devices. How the Evidence Gradient works

Triterpenes (also called triterpenoids) are fat-soluble compounds made by many plants and fungi. In mushrooms they are best known from reishi. Polysaccharides and triterpenes are the two main groups of active compounds in reishi (Zheng et al., 2020).

What Research Shows

Cell and animal studies report anti-inflammatory, antioxidant, and other effects for reishi and its triterpenes (Chan et al., 2021). Human evidence is limited and inconsistent, so these laboratory findings have not yet been confirmed in people.

Getting Them Out

Because triterpenes dissolve poorly in water, they are extracted with alcohol (Zheng et al., 2020). A tea or hot water extract of reishi carries mostly polysaccharides. See Dual Extraction.

References

Chan, S. W., Tomlinson, B., Chan, P., & Lam, C. W. K. (2021). The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk. Pharmaceutical Biology, 59(1), 1159–1169. https://doi.org/10.1080/13880209.2021.1969413

Zheng, S., Zhang, W., & Liu, S. (2020). Optimization of ultrasonic-assisted extraction of polysaccharides and triterpenoids from the medicinal mushroom Ganoderma lucidum and evaluation of their in vitro antioxidant capacities. PLoS ONE, 15(12), Article e0244749. https://doi.org/10.1371/journal.pone.0244749

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